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張國強

更新時間:2024-09-24 10:43:07點擊次數:

張國強,男,博士,副教授,碩士生導師,藥物化學專業教師。20126月本科畢業于Betvictor中文版;20156月于Betvictor中文版獲得藥物化學碩士學位,期間在北京大學藥學院進行聯合培養,師從李建恒/葉新山教授;20186月于南開大學藥學院獲得化學生物學博士學位,師從王鵬/趙炜教授。20189月進入南開大學藥物化學生物學國家重點實驗室進行博士後研究;20237月回到Betvictor中文版。目前主持一項國家級和一項省級課題,均在研;在AngewNat CommOCFEJMCACS Materials Letters等學術期刊發表SCI論文十多篇,目前已經申請數十件專利,且有一項專利已經授權,且該專利正在轉化。

郵箱:gqzhang@hbu.edu.cn

本人研究方向主要包括:1. 兼具抗凝與抗炎活性糖類新藥的開發; 2. 基于糖苷酶的前藥靶向遞送。

主持或參加科研項目(課題)情況

  • 國家自然科學基金青年科學基金項目,抗體導向的酶催化診療一體化探針在肝癌模型中的應用,項目編号:522031712023.01 – 2025.1230萬,在研,主持

  • 河北省高等學校科學技術研究項目青年拔尖人才項目,在肝正常組織中淬滅的餘輝探針在肝癌早期診斷和手術導航中的應用,10萬,2024.01-2026.12,主持

  • 中央高校基本科研業務費青年教師啟動項目,化學發光型納米探針在肝癌診斷中的應用,2019. 012019. 123萬元,結題,主持

    第一作者(含共同第一作者)與通訊作者論文

  1. Xingchen Duan,+ Guo-Qiang Zhang,+ Shenglu Ji, Yiming Zhang, Jun Li, Hanlin Ou, Zhiyuan Gao, Guangxue Feng, and Dan Ding* Activatable Persistent Luminescence from Porphyrin Derivatives and Supramolecular Probe with Imaging-Modality Transformable Characteristics for Improved Biological Application. Angew. Chem. Int. Ed., 2022, 61, e202116174, https://doi.org/10.1002/anie.202116174 (IF=16.823, 中科院1)

  2. Jisen Li#, Guo-Qiang Zhang#, Yufan Zhang, Youhong Tang, Dan Ding, Wen Li, Qian Liu. Building Highly Light-Harvesting Near-Infrared AIEgens Using Triazole-Based Luminescent Core for Improved Intravital Afterglow Imaging. Advanced Functional Materials, 2023, 2212380, https://doi.org/10.1002/adfm.202212380 (IF=19.9,中科院1)

  3. Kang Li, Xingchen Duan, Zhiyong Jiang, Dan Ding, Yuncong Chen*, Guo-Qiang Zhang* & Zhipeng Liu*. J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging. Nat. Commun., 2021, 12, 2376. https://doi.org/10.1038/s41467-021-22686-z. (IF=17.694, 中科院1)

  4. Guo-Qiang Zhang#, Hao Chang#, Zhiyuan Gao, Yang-ping Deng, Sheng Zeng, Luqing Shang, Dan Ding, Qian Liu. A neuraminidase-activatable NIR fluorescent probe for influenza virus ratiometric imaging in living cells and colorimetric detection on cotton swab. ACS Materials Letters, 2023, 5, 722−729. (IF= 11.1, 中科院1)

  5. Hongzhen Jin, Qiang Chen, Yan-Yan Zhang, Kai-Feng Hao, Guo-Qiang Zhang* and Wei Zhao*. Preactivation-based, iterative one-pot synthesis of anticoagulant pentasaccharide fondaparinux sodium. Org. Chem. Front., 2019, 6, 3116-3120. (IF=5.456, 中科院1)

  6. Guo-Qiang Zhang, Hongzhen Jin, Yunyan Zhao, Lina Guo, Xue Gao, Xiaoxue Wang, Shiyang Tie, Jie Shen, Peng George Wang, Hao Gan*, Huifei Cui*, Wei Zhao*. An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17. European Journal of Medicinal Chemistry, 2017, 126, 1039-1055. (IF=7.088, Q1)

  7. Guo-Qiang Zhang, Zhiyuan Gao, Jingtian Zhang, Hanlin Ou, Heqi Gao, Ryan T. K. Kwok, Dan Ding*, Ben Zhong Tang*. Wearable AIEgen-Based Lateral Flow Test Strip for Rapid Detection of SARS-CoV-2 RBD Protein and N Protein. Cell Reports Physical Science, 2022, https://doi.org/10.1016/j.xcrp.2022.100740 (IF=7.832, Q1)

  8. Guo-Qiang Zhang#, Weiwei Feng#, Zhiyuan Gao, Gao-Lan Zhang, Xinying Wu, Yating Xiao, Xun Li, Lei Zheng, Dan Ding, Jianshuang Guo*, Bo Situ*. A NIR ratiometric fluorescent biosensor for sensitive detection and imaging of α‑L‑fucosidase in living cells and HCC tumor-bearing mice. Aggregate, 2022, https://doi.org/10.1002/agt2.286. (即時IF>18.0)

  9. Huilin Xie, Jingtian Zhang, Chao Chen, Feiyi Sun, Haixiang Liu,Xinyuan He, Kristy W. K. Lam, Zhao Li, Jacky W. Y. Lam, Guo-Qiang Zhang,* Dan Ding, Ryan T. K. Kwok* and Ben Zhong Tang*. Sensitive and specific detection of peroxynitrite and in vivo imaging of inflammation by a “simple” AIE bioprobe. Mater. Chem. Front., 2021, 5, 1830-1835. (IF=8.683, Q1)

  10. Jing Gao, Junhua Wang, Xin Yue, Yuanzhu Zhou, Minghui Wang, Yiqing Sun, Qianyu Zhang, Zhiyuan Gao, Guo-Qiang Zhang*, Jing Shen*and Dan Ding*. Photostable Aggregation-Induced Emission Photosensitizer Nanoparticle/Hyaluronic Acid Hydrogel for Efficient Photodynamic Tooth Bleaching. ACS Applied Nano Materials, 2022, https://doi.org/10.1021/acsanm.1c03912. (IF=6.14, Q2)

  11. Yifang Huang, Weiwei Feng, Guo-Qiang Zhang, Yuling Qiu, Linlin Li, Liqiu Pan, Nannan Cao*. An Enzyme-activatable Dual-readout Probe for Sensitive β-Galactosidase Sensing and Escherichia Coli analysis. Frontiers in Bioengineering and Biotechnology, 2022, DOI: 10.3389/fbioe.2022.1052801 (IF=6.064, Q1).

  12. Hongzhen Jin, Kaixuan Wang, Kerui Ma, Wei Zhao, Guo-Qiang Zhang*. Preparation of rare L-idose derivatives from D-glucofuranose via neighboring acyl group assistance. Tetrahedron Letters, 2021, 73, 153135. (IF=2.032, Q3)

其它論文

  1. Guangxue Feng, Guo-Qiang Zhang, Dan Ding. Design of superior phototheranostic agents guided by Jablonski diagrams. Chem. Soc. Rev., 2020, 49, 8179-8234.

  2. Yao B, Zhao J, Ding S, Giel M-C, Zhang G, Ding D, Tang Y, Weng ZH, Hong Y, A novel red-emitting aggregation-induced emission probe for determination of β-glucosidase activity, Biomaterials (2023), doi: https://doi.org/10.1016/j.biomaterials.2023.122046.

  3. Zhang Yanyan, Hao Kaifeng, Zhang Guoqiang*, Zhao Wei. β-Stereoselectivity of Glucuronic Acid Analogues Mediated by 2-Cyanobenzyl Group. Chemical Journal of Chinese Universities, 2019, 40, 1904-1910.

  4. Jianshuang Guo, Guoqiang Zhang, Jing Ma, Caili Zhao, Qingqing Xue, Jiyan Wang, Wenjie Liu, Kaihui Liu, Haifeng Wang, Ning Liu, Qitao Song and Jing Li*. Detection and identification of O-GlcNAc-modified proteins using 6-azido-6-deoxy-N-acetyl-galactosamine. Org. Biomol. Chem., 2019, 17, 4326.

專利  

1.  趙炜,張國強,金洪真,王凱旋. 肝素五糖結構化合物, 公開(公告)号:CN114957354A(已授權)

2. 丁丹,張國強,唐本忠,鄭磊,司徒博. 一種2019-nCoV新型冠狀病毒抗體檢測裝置, 申請号:2020120186324.X

3. 丁丹,張國強,唐本忠,鄭磊,司徒博. 一種2019-nCoV新型冠狀病毒抗原檢測裝置, 申請号:202020185671.0

4. 丁丹,張國強,唐本忠,鄭磊,司徒博. 一種2019-nCoV新型冠狀病毒抗體檢測試劑及檢測裝置, 申請号:202010103382.6

5. 丁丹,張國強,唐本忠,鄭磊,司徒博. 一種2019-nCoV新型冠狀病毒抗原檢測試劑及檢測裝置, 申請号:202010103222.1

6. 丁丹,鄭磊,司徒博,張國強.一種新型抗體檢測試劑及其制備方法, 申請号:202010103200.5

7. 丁丹,鄭磊,司徒博,張國強. 一種新型抗原檢測試劑及其制備方法, 申請号:202010103204.3

8. 丁丹,高賀麒,張國強,章經天. 一種AIE分子及其合成方法, 申請号:202010105787.3

9. 丁丹,鄭磊,司徒博,張國強. 一種新型特異性蛋白檢測試劑及其制備方法, 申請号:202010103205.8

 

(編輯:姜浩)
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